Addendum to my previous reply. I’ve installed Pop!_OS on bare metal. The magnifier is marginally better. Scrolling to zoom doesn’t also pass the input to the current application causing a page to scroll at the same time. That’s good. Invert colors is present, but there’s no obvious quick way to switch between normal and inverted. There’s no options to change the size or color of the cursor, though I did find a config file /etc/environment with a cursor size setting. Unfortunately the cursor size depends on the currently focused app, so if the cursor is over the desktop or a component of the DE like the settings app, its size will reflect the setting in /etc/environment but if you move it over a Firefox window, for example, it will shrink.

Orca is as bad as ever, perhaps worse since there’s no obvious way in the GUI to change screen reader settings like verbosity and rate.

UPDATE:

Much of the documentation references options that are no longer present, I assume referring to GNOME rather than Cosmic. Docs on Github, for example, mention typing and pointing & clicking as options in the accessibility settings menu, but these are not present in Cosmic.

So I’m not much better off.

Currently trying Pop_OS in a VM.

Long way to go but the fact it presents the accessibility options the first time you log in post install shows some thought has been put into it. Magnifier is present, and unlike Mint there’s an invert color option. Haven’t explored enough to see if any of this can be globally bound to keyboard shortcuts. Orca still craps the bed as soon as it’s started but that might be due to the VM not playing nice with audio. My use case is reading text under the mouse. It has to be responsive and it has to read more than just a line. Paragraphs are usually the ideal.